Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_1575

Protein Name

Aquaporin-1

Gene Name

AQP1

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Length

271 amino acids

AlphaFoldDB

AF-Q9N2J4-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex; a multiprotein complex involved in the stability and shape of the erythrocyte membrane.

Sequence

MASEFKKKLFWRAVVAEFLAMILFVFISIGSALGFNYPVRNNQTAGAAQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLPDNSLGRNELAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSGPLAIGLSVALGHLLAIDYTGCGINPARSFGSSVITHNFKDHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYELDGDDINSRVEMKPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 58: "Substrate discrimination"; SITE 182: "Substrate discrimination"; SITE 191: "Hg(2+)-sensitive residue"; SITE 197: "Substrate discrimination";

Disease

Location

DOI ID

10.1016/s0005-2736(99)00218-7

RefSeq

NP_001003130.1